Layer-by-layer biofabrication of coronary covered stents with clickable elastin-like recombinamers

Producción CientíficaCoronary artery disease is the leading cause of death around the world. Endovascular stenting is the preferred treatment option to restore blood flow in the coronary arteries due to the lower perioperative morbidity when compared with more invasive treatment options. However, stent failure is still a major clinical problem, and further technological solutions are required to improve the performance of current stents. Here, we developed coronary stents covered with elastin-like recombinamers (ELRs) by exploiting a layer-by-layer technique combined with catalyst-free click chemistry. The resulting ELR-covered stents were intact after an in vitro simulated implantation procedure by balloon dilatation, which evidenced the elastic performance of the membrane. Additionally, the stents were mechanically stable under high flow conditions, which is in agreement with the covalent and stable nature of the click chemistry crosslinking strategy exploited during the ELR-membrane manufacturing and the successful embedding of the stent. Minimal platelet adhesion was detected after blood exposure in a Chandler loop as shown by scanning electron microscopy. The seeding of human endothelial progenitor cells (EPCs) on the ELR-membranes resulted in a confluent endothelial layer. These results prove the potential of this strategy to develop an advanced generation of coronary stents, with a stable and bioactive elastin-like membrane to exclude the atherosclerotic plaque from the blood stream or to seal coronary perforations and aneurysms, while providing a luminal surface with minimal platelet adhesion and favouring endothelialization.German federal and state governments (project StUpPD_330-18)Ministerio de Economía, Industria y Competitividad (projects PCIN-2015-010 / MAT2016-78903-R)Junta de Castilla y León (project VA317P18

СИМВОЛИКА «ХРАМА В СЕРДЦЕ» ВО ФРАНЦУЗСКОЙ РОМАНТИЧЕСКОЙ ЛИТЕРАТУРЕ 1820-Х ГГ.

В статье романтическая символика храма и сердца рассматривается в аналитической традиции Г. Башляра. Французская романтическая поэзия перших десятиріч ХІХ ст. сохранила руссоистскую стилистику, однако актуализировала в новой мифопоэтической форме стихию человеческих чувств в их связи со стихиями природы и трансендентностью

Optimization of Energy Consumption in The Residential Sector, Using Automated Control Systems

With limited energy resources for sustainable and balanced national development it is becoming more and more important to solve tasks of optimization of energy consumption. This optimization is important not only for major Russian companies (which provide major share of tax inflows for the state budget), but also for homes in order toreduce the energy consumption. This article discusses a complex approach in the field monitoring and energy management of apartment buildings as part of the energy management program using an automated thermal and electrical energy management system developed by NGO VEST in Tomsk. It is shown that the power monitoring data allow to make economically effective decisions in reducing energy consumption costs in residential buildings. The creation of the Analytical Center and the use of an automated energy management system give the opportunity to reduce costs of heat consumption in apartment buildings and, as a consequence, increase the efficiency of use of budgetary funds, used for subsidizing the northern regions of Russia

Virtual design bureau

В статье описывается краткая история Виртуального конструкторского бюро космического приборостроения за 5 лет его существования. В статье можно прочитать об основных, но при этом наиболее важных событиях в жизни ВКБ и кафедры точного приборостроения за этот период. ВКБ сыграло значительную роль в определении направления развитии кафедры. Самыми значимыми проектами являются создание студенческого Центра управления полетами космическими аппаратами и участие взапуске спутника "Томск-ТПУ-120".The article describes a brief 5-year history of the Virtual Design Bureau. In the article you can read about the most important events in the life of the VDB and the Department of Precision Instrument Making for this period. VDB played a significant role in determining the department development direction. The most significant projects are the creation of a student space flight control center and participation in the launch of the Tomsk-TPU-120 satellite

Разработка теплообменного оборудования для установки получения легкого газойля

Объектом исследования является кожухотрубчатый теплообменник с линзовым компенсатором для нагрева вакуумного дистиллята. Цель работы–расчет и выбор аппарата для нагрева вакуумного дистиллята легким газойлем. В процессе исследования проведены тепловые, конструктивные и механические расчеты оборудования. Основные конструктивные, технологические и технико-эксплуатационные характеристики теплообменника: диаметр кожуха 1400 мм, длина труб 6 м, диаметр труб 25х2,5 мм, с линзовым компенсатором, четырехходовой, горизонтальный.The object of the study is a shell-and-tube heat exchanger with a lens compensator for heating a vacuum distillate. The purpose of the work is the calculation and selection of the apparatus for heating vacuum distillate with light gas oil. In the process of the study, thermal, structural and mechanical calculations of the equipment were carried out. The main design, technological and technical and operational characteristics of the heat exchanger: casing diameter 1400 mm, length of pipes 6 m, diameter of pipes 25x2.5 mm, with a lens compensator, four-way, horizontal

Macroporous click-elastin-like hydrogels for tissue engineering applications

Producción CientíficaElastin is a key extracellular matrix (ECM) protein that imparts functional elasticity to tissues and therefore an attractive candidate for bioengineering materials. Genetically engineered elastin-like recombinamers (ELRs) maintain inherent properties of the natural elastin (e.g. elastic behavior, bioactivity, low thrombogenicity, inverse temperature transition) while featuring precisely controlled composition, the possibility for biofunctionalization and non-animal origin. Recently the chemical modification of ELRs to enable their crosslinking via a catalyst-free click chemistry reaction, has further widened their applicability for tissue engineering. Despite these outstanding properties, the generation of macroporous click-ELR scaffolds with controlled, interconnected porosity has remained elusive so far. This significantly limits the potential of these materials as the porosity has a crucial role on cell infiltration, proliferation and ECM formation. In this study we propose a strategy to overcome this issue by adapting the salt leaching/gas foaming technique to click-ELRs. As result, macroporous hydrogels with tuned pore size and mechanical properties in the range of many native tissues were reproducibly obtained as demonstrated by rheological measurements and quantitative analysis of fluorescence, scanning electron and two-photon microscopy images. Additionally, the appropriate size and interconnectivity of the pores enabled smooth muscle cells to migrate into the click-ELR scaffolds and deposit extracellular matrix. The macroporous structure together with the elastic performance and bioactive character of ELRs, the specificity and non-toxic character of the catalyst-free click-chemistry reaction, make these scaffolds promising candidates for applications in tissue regeneration. This work expands the potential use of ELRs and click chemistry systems in general in different biomedical fields.Ministerio de Economía, Industria y Competitividad (Projects MAT2013-42473-R, MAT2015-68901-R, MAT2016- 78903-R)Junta de Castilla y León (programa de apoyo a proyectos de investigación - Ref. VA313U14, VA015U16 y PCIN-2015-010)gobierno federal y estatal de Alemania en el marco del Programa de Posición Rotacional i³tm (2014-R4-01) y del Programa START de la Facultad de Medicina de la Universidad de Aachen (proyecto nº 691713),el centro de imágenes del Centro Interdisciplinario de Investigación Clínica (IZKF) de la Facultad de Medicina de la Universidad de Aache

Potential applications of automated video-image analysis in the pelagic and demersal environtment including the deep-sea

Martech 2009 Third Marine Technology Workshop, 19-20 november 2009, Vilanova i la Geltrú, Barcelona.-- 2 pages, 3 figuresThis work was funded by the project High Vision (DM 19177/7303/08) from the Italian Ministry of Agricultural, Food and Forestry PoliticsPeer reviewe